Topical Permethrin Exposure Causes Thymic Atrophy and Persistent Inhibition of the Contact Hypersensitivity Response in C57Bl/6 Mice
نویسندگان
چکیده
1Department of Biomedical Sciences and Pathobiology,Virginia-MarylandRegional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA 2College of Pharmacy and Health Sciences, University of Louisiana at Monroe, Monroe, Louisiana, USA 3The Institute for Global Risk Research, LLC, Bethesda, Maryland, USA 4U.S. Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland, USA
منابع مشابه
Oral tolerance for delayed type hypersensitivity contribution of local and peripheral mechanisms
Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...
متن کاملRestorative Effect of Vitamin E on some Immunological Parameters of Sub-Lethal γ-Irradiated BALB/c Mice
Elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. Therefore, we made attempts to investigate the protective effect of vitamin E (vit-E), a biological antioxidant in BALB/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. Several groups of mice were selected and exposed to sub-lethal g -irra...
متن کاملWestern Blot Analysis of Sera from Leishmania major-Infected BALB/c and C57BL/6 Mice
In Leishmania (L.) major-infected BALB/c mice Th2-type cells results in disease progression, whereas C57BL/6-infected mice mount a Th1-type response, which leads to control of the infection. Th2 response correlates with IgG1 whereas, Th1 response supports switching to IgG2a subclasses. Since IgG isotype-dominated response depends on different CD4 + T cell subsets, we studied the antigenic profi...
متن کاملInfluence of Permethrin and Cypermethrin on Behavior in the Mouse
Permethrin and Cypermethrin are synthetic pyrethroids, belonging to a group of insecticides with low mammalian toxicity and high insecticidal activity. The present study evaluated sub-acute toxicity of dermally administrated permethrin and cypermethrin in mice. Behavioral examination included assessments of lethality, weight gain, grooming, analgesymetry, anxiety, grasping, motor activity, and ...
متن کاملImmunogenicity Evaluation of a DNA Vaccine Expressing the Hepatitis C Virus Non-Structural Protein 2 Gene in C57BL/6 Mice
Backgrounds: Most of the hepatitis C virus (HCV) infections elicit poor immune responses and 75% to 85% of cases become chronic therefore, the development of an effective vaccine against HCV is of paramount importance. In this study, we aimed to evaluate co-administration of HCV non-Structural Protein 2 and IL-12 DNA vaccines in C57BL/6 mice. Methods: A plasmid encoding full-length HCV NS2 prot...
متن کامل